For instance, John makes it a point to tell us that 666 is the number of a man (whether the beast is a man or that 6 is the number of man). John was well aware that man was created on the sixth day, and thus, (I believe) was thinking this when mentioning the number 666.
Paul says to the Corinthians that he has come to them "3" times and that by the mouth of 2 or "3" witnesses that every word would be established (2 Cor. 13:1). Was Paul being cute in taking this Moses command out of context? By that I mean, its obvious both Jesus and Moses were referring to 2 or 3 people as witnesses and not the visiting of an Apostle to the same city 3 times as representing a witness. The number "3" in this instance seemed to have importance to Paul, and so it should also mean something to me.
So then, if the writers of the Word make an issue of numbers, I believe we should not be ignorant of their importance. Peter told me not to be ignorant of this very thing, "1" day is as a "1,000" years and a "1,000" years as "1" day. I may not be able to expound on the importance of 1 or 1,000, but it must be important if Peter says we shouldn't be ignorant of it (2 Pet. 3:8).