Rev 13 refers to a new empire (a beast) that arises from the nations of the sea. It will resemble the leopard. One way of interpreting this is that a future empire will arise from the nations and peoples of the Meditteranean, and this new empire will resemble the "leopard empire" of Alexander the Great, referred to in Daniel 7. If there is a new empire arising this means that it must include the regions of Alexander's Empire:
Libya, Egypt, Israel, Lebanon, Syria, Turkey, Greece, Iraq, Iran, Afghanistan.
Horns represent countries or their leaders, reading Daniel 7 this indicates that the fourth empire-Western Europe will set up a small horn, a little country. This little horn could easily be Israel, conquered by Western Europe during WW2 and then set up in 1948. This country will rule over ten regions (Middle East countries). Three of these ten countries will fall directly to Israel and its allies, namely Iraq, Iran, Afghanistan.
Rev 17 indicates that this future empire that arises used to exist before, and yet when it re-appears it amazes only the unbelievers of the world. This hints that believers were prophetically expecting this country to re-arise:
And they that dwell on the earth shall wonder, `they' whose name hath not been written in the book of life from the foundation of the world, when they behold the beast, how that he was, and is not, and shall come.
In 1948 Israel amazed the world by re-appearing, and the world is still reeling from it. This beast country that re-appears has the manipulation of Europe behind it, the harlot (Europa) sits on the beast as per Rev 17.
My conclusion: Israel is a likely candidate to be the future leading country in a ten nation Middle Eastern Confederation that will resemble Alexander's Empire. Three of those ten nations will fall directly to Israel and its ally the USA, these 3 countries are Iraq, Iran, and Afghanistan, and these are the 3 horns of the ten horns of Daniel 7. All verses about the beast uniquely fit Israel well.
DAN 7:20 and concerning the ten horns that were on its head, and the other `horn' which came up, and before which three fell, even that horn that had eyes, and a mouth that spake great things, whose look was more stout than its fellows.